Version 5.4
Bos taurus Gene: SHBG
Summary
InnateDB Gene IDBG-635125.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHBG
Gene Name sex hormone-binding globulin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004226
Encoded Proteins
IDBP-686936
sex hormone-binding globulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129214:
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27955573-27960099
Strand Forward strand
Band
Transcripts
ENSBTAT00000005537 ENSBTAP00000005537
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129214
View Gene Order
ENSMUSG00000005202
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
Cross-References
SwissProt
TrEMBL A5PKC2 Q6T181 Q6T182
UniProt Splice Variant
Entrez Gene 404182
UniGene Bt.60925
RefSeq NM_001098858 XM_005220313 XM_005220314 XM_005220315 XM_005220316
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY443491 AY443492 BC142435 DAAA02048796
GenPept AAI42436 AAR17085 AAR17086
RNA Seq Atlas 404182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca