InnateDB: Systems Biology of the Innate Immune Response

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7613946-7633383

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000340624	ENSP00000345675
ENST00000380450	ENSP00000369816
ENST00000441599	ENSP00000393426
ENST00000416273	ENSP00000388867
ENST00000571153	ENSP00000458858
ENST00000572182	ENSP00000458816
ENST00000575903	ENSP00000458973
ENST00000576478	ENSP00000461133
ENST00000575314	ENSP00000458559
ENST00000570353	ENSP00000458199
ENST00000575618	ENSP00000459826
ENST00000570547	ENSP00000458875
ENST00000576728	ENSP00000459620
ENST00000576152	ENSP00000461743
ENST00000570527	ENSP00000461162
ENST00000572262	ENSP00000459999
ENST00000575729	ENSP00000458719
ENST00000574539	ENSP00000458181
ENST00000576830	ENSP00000460219
ENST00000576747
ENST00000624152

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005497	androgen binding
GO:0005515	protein binding

Biological Process

GO:0007285

primary spermatocyte growth

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005202

View Gene Order

ENSBTAG00000004226

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

ar_nongenomic_pathway

Nongenotropic Androgen signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.632235

RefSeq

NM_001040 NM_001146279 NM_001146280 NM_001146281 NM_001289113 NM_001289114 NM_001289115 NM_001289116 XM_005256762 XM_005256765 XM_006721569

HUGO

OMIM

CCDS

CCDS11117 CCDS54082 CCDS54083 CCDS58513 CCDS73961 CCDS73962

HPRD

01646

IMGT

EMBL

GenPept

RNA Seq Atlas