Homo sapiens Gene: SHBG
Summary
InnateDB Gene IDBG-26209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHBG
Gene Name sex hormone-binding globulin
Synonyms ABP; SBP; TEBG;
Species Homo sapiens
Ensembl Gene ENSG00000129214
Encoded Proteins
sex hormone-binding globulin
sex hormone-binding globulin
sex hormone-binding globulin
sex hormone-binding globulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7613946-7633383
Strand Forward strand
Band p13.1
Transcripts
ENST00000340624 ENSP00000345675
ENST00000380450 ENSP00000369816
ENST00000441599 ENSP00000393426
ENST00000416273 ENSP00000388867
ENST00000571153 ENSP00000458858
ENST00000572182 ENSP00000458816
ENST00000575903 ENSP00000458973
ENST00000576478 ENSP00000461133
ENST00000575314 ENSP00000458559
ENST00000570353 ENSP00000458199
ENST00000575618 ENSP00000459826
ENST00000570547 ENSP00000458875
ENST00000576728 ENSP00000459620
ENST00000576152 ENSP00000461743
ENST00000570527 ENSP00000461162
ENST00000572262 ENSP00000459999
ENST00000575729 ENSP00000458719
ENST00000574539 ENSP00000458181
ENST00000576830 ENSP00000460219
ENST00000576747
ENST00000624152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 64 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005497 androgen binding
GO:0005515 protein binding
Biological Process
GO:0007285 primary spermatocyte growth
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Nongenotropic Androgen signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632235
RefSeq NM_001040 NM_001146279 NM_001146280 NM_001146281 NM_001289113 NM_001289114 NM_001289115 NM_001289116 XM_005256762 XM_005256765 XM_006721569
HUGO
OMIM
CCDS CCDS11117 CCDS54082 CCDS54083 CCDS58513 CCDS73961 CCDS73962
HPRD 01646
IMGT
EMBL
GenPept
RNA Seq Atlas