InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GABBR1

Summary

InnateDB Gene

IDBG-635135.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABBR1

Gene Name

gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017239

Encoded Proteins

IDBP-686974

gamma-aminobutyric acid type B receptor subunit 1 isoform 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204681:
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:28775534-28803895

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022907

ENSBTAP00000022907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004965	G-protein coupled GABA receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007214	gamma-aminobutyric acid signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0038037	G-protein coupled receptor dimeric complex
GO:0038039	G-protein coupled receptor heterodimeric complex
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane