Version 5.4
Homo sapiens Gene: RBM3
Summary
InnateDB Gene IDBG-63532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBM3
Gene Name RNA binding motif (RNP1, RRM) protein 3
Synonyms IS1-RNPL; RNPL
Species Homo sapiens
Ensembl Gene ENSG00000102317
Encoded Proteins
IDBP-63536
RNA binding motif (RNP1, RRM) protein 3
IDBP-63540
RNA binding motif (RNP1, RRM) protein 3
IDBP-63542
RNA binding motif (RNP1, RRM) protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48574449-48579066
Strand Forward strand
Band p11.23
Transcripts
ENST00000376759 ENSP00000365950
ENST00000376755 ENSP00000365946
ENST00000354480 ENSP00000346473
ENST00000472897
ENST00000488216
ENST00000466764
ENST00000490127
ENST00000489344
ENST00000491240
ENST00000485213
ENST00000491236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043023 ribosomal large subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006396 RNA processing
GO:0006412 translation
GO:0006417 regulation of translation
GO:0009409 response to cold
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015934 large ribosomal subunit
GO:0030425 dendrite
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301404
RefSeq NM_006743
HUGO
OMIM
CCDS CCDS14301
HPRD 02067
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca