InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM3

Summary

InnateDB Protein

IDBP-63540.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM3

Protein Name

RNA binding motif (RNP1, RRM) protein 3

Synonyms

IS1-RNPL; RNPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000365946

InnateDB Gene

IDBG-63532 (RBM3)

Protein Structure

UniProt Annotation

Function

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in mRNA granules in dentrites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding