Version 5.4
Bos taurus Gene: PEPD
Summary
InnateDB Gene IDBG-635331.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEPD
Gene Name xaa-Pro dipeptidase
Synonyms prolidase
Species Bos taurus
Ensembl Gene ENSBTAG00000031941
Encoded Proteins
IDBP-687167
xaa-Pro dipeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124299:
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:44018758-44137173
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045260 ENSBTAP00000042663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124299
View Gene Order
ENSMUSG00000063931
View Gene Order
Cross-References
SwissProt
TrEMBL A1L568 F6Q234
UniProt Splice Variant
Entrez Gene 615158
UniGene Bt.53798
RefSeq NM_001080318
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134540 BT029855 DAAA02046876 DAAA02046877
GenPept AAI34541 ABM06110
RNA Seq Atlas 615158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca