Version 5.4
Homo sapiens Gene: PEPD
Summary
InnateDB Gene IDBG-42695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEPD
Gene Name peptidase D
Synonyms PROLIDASE
Species Homo sapiens
Ensembl Gene ENSG00000124299
Encoded Proteins
IDBP-42697
peptidase D
IDBP-236237
peptidase D
IDBP-377301
peptidase D
IDBP-764210
IDBP-807927
peptidase D
IDBP-807924
peptidase D
IDBP-807921
peptidase D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:33386950-33521794
Strand Reverse strand
Band q13.11
Transcripts
ENST00000244137 ENSP00000244137
ENST00000397032 ENSP00000380226
ENST00000436370 ENSP00000391890
ENST00000588719
ENST00000588328 ENSP00000468516
ENST00000591968
ENST00000593163
ENST00000590408 ENSP00000476869
ENST00000589598
ENST00000590755 ENSP00000476667
ENST00000593085
ENST00000590731
ENST00000609145 ENSP00000476514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0016805 dipeptidase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0008152 metabolic process
GO:0030574 collagen catabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063931
View Gene Order
ENSBTAG00000031941
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.36473
RefSeq NM_000285 NM_001166056 NM_001166057
HUGO
OMIM
CCDS CCDS42544 CCDS54244 CCDS54245
HPRD 01358
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca