Version 5.4
| Bos taurus Gene: XPO1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-635403.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | XPO1 | ||||||||||||||||||
| Gene Name | exportin-1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000013254 | ||||||||||||||||||
| Encoded Proteins |
exportin 1 (CRM1 homolog, yeast)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082898:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:60068221-60109922 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 141 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Cyclin A/B1 associated events during G2/M transition pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
HuR stabilizes mRNA pathway
Rev-mediated nuclear export of HIV RNA pathway
NEP/NS2 Interacts with the Cellular Export Machinery pathway
Late Phase of HIV Life Cycle pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Influenza Infection pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
deactivation of the beta-catenin transactivating complex pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Anaphase pathway
TCF dependent signaling in response to WNT pathway
G2/M Transition pathway
TGFBR1 KD Mutants in Cancer pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
HIV Infection pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Influenza Life Cycle pathway
Mitotic G2-G2/M phases pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Export of Viral Ribonucleoproteins from Nucleus pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Mitotic Metaphase and Anaphase pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Disease pathway
Signaling by Wnt pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Signaling by WNT in cancer pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Loss of Function of SMAD4 in Cancer pathway
HuR stabilizes mRNA pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
M Phase pathway
TGF-beta receptor signaling activates SMADs pathway
Loss of Function of TGFBR2 in Cancer pathway
deactivation of the beta-catenin transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Mitotic G2-G2/M phases pathway
TCF dependent signaling in response to WNT pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Cyclin A/B1 associated events during G2/M transition pathway
Gene Expression pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Mitotic Anaphase pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG |
RNA transport pathway
RNA transport pathway
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| INOH | |||||||||||||||||||
| PID NCI |
FoxO family signaling
Signaling events mediated by HDAC Class I
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
Signaling events mediated by HDAC Class II
Canonical NF-kappaB pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Sumoylation by RanBP2 regulates transcriptional repression
Hedgehog signaling events mediated by Gli proteins
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | E1BE98 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 510568 | ||||||||||||||||||
| UniGene | Bt.105511 Bt.9586 | ||||||||||||||||||
| RefSeq | NM_001192261 XM_005212771 XM_005212772 XM_005212773 XM_005212774 | ||||||||||||||||||
| HUGO | HGNC:12825 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | DAAA02031378 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 510568 | ||||||||||||||||||