Version 5.4
Bos taurus Gene: SSH1
Summary
InnateDB Gene IDBG-635503.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSH1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018825
Encoded Proteins
IDBP-687346
slingshot homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084112:
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66389870-66434922
Strand Forward strand
Band
Transcripts
ENSBTAT00000025062 ENSBTAP00000025062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000902 cell morphogenesis
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0030036 actin cytoskeleton organization
GO:0032268 regulation of cellular protein metabolic process
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
GO:0071318 cellular response to ATP
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000084112
View Gene Order
ENSMUSG00000042121
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL E1BIZ2
UniProt Splice Variant
Entrez Gene 538233
UniGene Bt.25416
RefSeq XM_002694601 XM_618431
HUGO HGNC:30579
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045487
GenPept
RNA Seq Atlas 538233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca