InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SSH1

Summary

InnateDB Gene

IDBG-55527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSH1

Gene Name

slingshot homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000084112

Encoded Proteins

IDBP-55529

slingshot homolog 1 (Drosophila)

IDBP-55533

slingshot homolog 1 (Drosophila)

IDBP-597127

slingshot homolog 1 (Drosophila)

IDBP-600670

slingshot homolog 1 (Drosophila)

IDBP-598520

slingshot homolog 1 (Drosophila)

IDBP-594343

slingshot homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:108778192-108857590

Strand

Reverse strand

Band

q24.11

Transcripts

ENST00000326495	ENSP00000315713
ENST00000326470	ENSP00000326107
ENST00000546433	ENSP00000447629
ENST00000551165	ENSP00000448824
ENST00000547862
ENST00000548522	ENSP00000448586
ENST00000547381
ENST00000546697	ENSP00000446652
ENST00000546812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003779	actin binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0000902	cell morphogenesis
GO:0006470	protein dephosphorylation
GO:0008064	regulation of actin polymerization or depolymerization
GO:0010591	regulation of lamellipodium assembly
GO:0016311	dephosphorylation
GO:0030036	actin cytoskeleton organization
GO:0032268	regulation of cellular protein metabolic process
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0050770	regulation of axonogenesis
GO:0071318	cellular response to ATP

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0030496	midbody
GO:0032154	cleavage furrow

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042121

View Gene Order

ENSBTAG00000018825

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

INOH

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

fgf_pathway

FGF signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.199763 Hs.605559 Hs.609939

RefSeq

NM_001161330 NM_001161331 NM_018984 XM_005268984 XM_005268985 XM_005268986 XM_006719466

HUGO

OMIM

CCDS

CCDS53825 CCDS55882 CCDS9121

HPRD

09486

IMGT

EMBL

GenPept

RNA Seq Atlas