Version 5.4
Bos taurus Gene: ARRB1
Summary
InnateDB Gene IDBG-635576.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARRB1
Gene Name Beta-arrestin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020485
Encoded Proteins
IDBP-687437
Beta-arrestin-1
IDBP-687439
Beta-arrestin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137486:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:55255745-55329451
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027296 ENSBTAP00000027296
ENSBTAT00000045006 ENSBTAP00000042435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 216 interaction(s) predicted by orthology.
Predicted by orthology
Total 216 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031701 angiotensin receptor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G-protein coupled receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006810 transport
GO:0007165 signal transduction
GO:0007602 phototransduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032092 positive regulation of protein binding
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035066 positive regulation of histone acetylation
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043149 stress fiber assembly
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043547 positive regulation of GTPase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090240 positive regulation of histone H4 acetylation
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031143 pseudopodium
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137486
View Gene Order
ENSMUSG00000018909
View Gene Order
Pathways
NETPATH
REACTOME
REACT_221284
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_227813
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_220704
Signaling by NOTCH pathway
REACT_213874
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_219531
Golgi Associated Vesicle Biogenesis pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_204419
Signaling by NOTCH1 in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_215912
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_216751
Clathrin derived vesicle budding pathway
REACT_225877
Signaling by NOTCH1 pathway
REACT_211153
trans-Golgi Network Vesicle Budding pathway
REACT_227244
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_205891
Lysosome Vesicle Biogenesis pathway
REACT_225248
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_204471
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
NetPath_25
FSH pathway
REACTOME
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa04744
Phototransduction pathway
mmu04010
MAPK signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
mmu04744
Phototransduction pathway
INOH
PID NCI
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt P17870
TrEMBL F1MZR6
UniProt Splice Variant
Entrez Gene 281637
UniGene Bt.52082
RefSeq NM_174243 XM_005216233 XM_005216234 XM_005216235 XM_005216236
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041063 DAAA02041064 M33601
GenPept AAA30387
RNA Seq Atlas 281637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca