InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARRB1

Summary

InnateDB Gene

IDBG-64687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARRB1

Gene Name

arrestin, beta 1

Synonyms

ARB1; ARR1

Species

Homo sapiens

Ensembl Gene

ENSG00000137486

Encoded Proteins

IDBP-64691

arrestin, beta 1

IDBP-381126

arrestin, beta 1

IDBP-588980

arrestin, beta 1

IDBP-590117

arrestin, beta 1

IDBP-600635

arrestin, beta 1

IDBP-592535

arrestin, beta 1

IDBP-589306

arrestin, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75264182-75351705

Strand

Reverse strand

Band

q13.4

Transcripts

ENST00000360025	ENSP00000353124
ENST00000420843	ENSP00000409581
ENST00000532447	ENSP00000436530
ENST00000531012
ENST00000529741
ENST00000532525	ENSP00000433171
ENST00000524400	ENSP00000434196
ENST00000533609	ENSP00000436352
ENST00000527385	ENSP00000433137
ENST00000530086
ENST00000529280
ENST00000533255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 293 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	293 [view]
Protein-Protein	292 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005096	GTPase activator activity
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031701	angiotensin receptor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002031	G-protein coupled receptor internalization
GO:0002092	positive regulation of receptor internalization
GO:0006366	transcription from RNA polymerase II promoter
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007596	blood coagulation
GO:0007602	phototransduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0030168	platelet activation
GO:0031397	negative regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032092	positive regulation of protein binding
GO:0032715	negative regulation of interleukin-6 production
GO:0032717	negative regulation of interleukin-8 production
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035025	positive regulation of Rho protein signal transduction
GO:0035066	positive regulation of histone acetylation
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043149	stress fiber assembly
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043547	positive regulation of GTPase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061024	membrane organization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090240	positive regulation of histone H4 acetylation

Cellular Component

GO:0000139	Golgi membrane
GO:0000785	chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030659	cytoplasmic vesicle membrane
GO:0031143	pseudopodium
GO:0031410	cytoplasmic vesicle