Version 5.4
Bos taurus Gene: TDP2
Summary
InnateDB Gene IDBG-635578.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDP2
Gene Name Tyrosyl-DNA phosphodiesterase 2
Synonyms TTRAP
Species Bos taurus
Ensembl Gene ENSBTAG00000000365
Encoded Proteins
IDBP-687419
Tyrosyl-DNA phosphodiesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111802:
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:32849318-32861445
Strand Forward strand
Band
Transcripts
ENSBTAT00000000472 ENSBTAP00000000472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0036317 tyrosyl-RNA phosphodiesterase activity
GO:0046872 metal ion binding
GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity
Biological Process
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111802
View Gene Order
ENSMUSG00000035958
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
Cross-References
SwissProt A7YWI9
TrEMBL
UniProt Splice Variant
Entrez Gene 507579
UniGene Bt.13626 Bt.68977
RefSeq NM_001105341 XM_005223749
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134603
GenPept AAI34604
RNA Seq Atlas 507579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca