Version 5.4
Homo sapiens Gene: TDP2
Summary
InnateDB Gene IDBG-65484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDP2
Gene Name tyrosyl-DNA phosphodiesterase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111802
Encoded Proteins
IDBP-65486
tyrosyl-DNA phosphodiesterase 2
IDBP-65488
tyrosyl-DNA phosphodiesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:24649977-24667033
Strand Reverse strand
Band p22.3
Transcripts
ENST00000378198 ENSP00000367440
ENST00000341060 ENSP00000345345
ENST00000478507
ENST00000478285
ENST00000480495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003714 transcription corepressor activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0030145 manganese ion binding
GO:0036317 tyrosyl-RNA phosphodiesterase activity
GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity
Biological Process
GO:0006302 double-strand break repair
GO:0007166 cell surface receptor signaling pathway
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035958
View Gene Order
ENSBTAG00000000365
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
Cross-References
SwissProt
TrEMBL X6R5A3
UniProt Splice Variant
Entrez Gene 51567
UniGene Hs.731481
RefSeq NM_016614
HUGO HGNC:17768
OMIM 605764
CCDS CCDS4557
HPRD 05771
IMGT
EMBL AL031775 CH471087
GenPept EAW55459
RNA Seq Atlas 51567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca