Version 5.4
Bos taurus Gene: PARK2
Summary
InnateDB Gene IDBG-635722.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARK2
Gene Name E3 ubiquitin-protein ligase parkin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018996
Encoded Proteins
IDBP-687598
Truncated parkin variant SV6DEL
IDBP-687602
Truncated parkin variant SV6DEL
IDBP-687603
Truncated parkin variant SV6DEL
IDBP-687605
Truncated parkin variant SV6DEL
IDBP-687608
Truncated parkin variant SV6DEL
IDBP-687609
Truncated parkin variant SV6DEL
IDBP-687610
Truncated parkin variant SV6DEL
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20457763
[Homo sapiens] PARK2 was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy; PARK2 promotes mitophagy by catalyzing mitochondrial ubiquitination, which in turn recruits ubiquitin-binding autophagy components, HDAC6 and p62, leading to mitochondrial clearance.
PMID 24005326
[Homo sapiens] PARK2 is important for innate defence against M. tuberculosis for having a role in ubiquitin-mediated autophagy of M. tuberculosis
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185345:
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:98421510-99568077
Strand Reverse strand
Band
Transcripts
ENSBTAT00000062978 ENSBTAP00000055410
ENSBTAT00000065043 ENSBTAP00000054449
ENSBTAT00000064741 ENSBTAP00000055427
ENSBTAT00000064168 ENSBTAP00000055262
ENSBTAT00000025286 ENSBTAP00000025286
ENSBTAT00000063967 ENSBTAP00000056268
ENSBTAT00000064521 ENSBTAP00000054593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 126 interaction(s) predicted by orthology.
Predicted by orthology
Total 126 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0051087 chaperone binding
GO:0061630 ubiquitin protein ligase activity
GO:1990381 ubiquitin-specific protease binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000422 mitochondrion degradation
GO:0001933 negative regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0001964 startle response
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0008219 cell death
GO:0008344 adult locomotory behavior
GO:0010506 regulation of autophagy
GO:0016567 protein ubiquitination
GO:0019538 protein metabolic process
GO:0032232 negative regulation of actin filament bundle assembly
GO:0033132 negative regulation of glucokinase activity
GO:0035249 synaptic transmission, glutamatergic
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044257 cellular protein catabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046928 regulation of neurotransmitter secretion
GO:0050804 regulation of synaptic transmission
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051865 protein autoubiquitination
GO:0060548 negative regulation of cell death
GO:0070534 protein K63-linked ubiquitination
GO:0070842 aggresome assembly
GO:0070936 protein K48-linked ubiquitination
GO:0070997 neuron death
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1901215 negative regulation of neuron death
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016235 aggresome
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185345
View Gene Order
ENSMUSG00000023826
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05012
Parkinson's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu05012
Parkinson's disease pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.108747 Bt.61689
RefSeq NM_001199065
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca