InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VAV3

Summary

InnateDB Gene

IDBG-635847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAV3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031575

Encoded Proteins

IDBP-687800

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134215:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:35428177-35861571

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020771

ENSBTAP00000020771

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006906	vesicle fusion
GO:0006974	cellular response to DNA damage stimulus
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0016477	cell migration
GO:0030031	cell projection assembly
GO:0030032	lamellipodium assembly
GO:0030593	neutrophil chemotaxis
GO:0030890	positive regulation of B cell proliferation
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000134215

View Gene Order

ENSMUSG00000033721

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

NetPath_21

RANKL pathway

REACTOME

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_1695

GPVI-mediated activation cascade pathway

REACT_13638

NRAGE signals death through JNK pathway

REACT_18407

G alpha (12/13) signalling events pathway

REACT_11051

Rho GTPase cycle pathway

REACT_111045

Developmental Biology pathway

REACT_11061

Signalling by NGF pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_12529

Signaling by VEGF pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_228016

VEGFR2 mediated vascular permeability pathway

REACT_18266

Axon guidance pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_13776

p75 NTR receptor-mediated signalling pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_6900

Immune System pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_13720

Cell death signalling via NRAGE, NRIF and NADE pathway

REACT_228189

EPH-ephrin mediated repulsion of cells pathway

REACT_228170

EPH-Ephrin signaling pathway

REACT_163834

FCERI mediated Ca+2 mobilization pathway

REACT_163701

FCERI mediated MAPK activation pathway

REACT_604

Hemostasis pathway

REACT_239142

Innate Immune System pathway

REACT_198374

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_223625

GPCR downstream signaling pathway

REACT_224553

Hemostasis pathway

REACT_254215

Signaling by GPCR pathway

REACT_227951

Signaling by VEGF pathway

REACT_209641

NRAGE signals death through JNK pathway

REACT_230745

Immune System pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_206918

Signaling by Rho GTPases pathway

REACT_204413

Cell death signalling via NRAGE, NRIF and NADE pathway

REACT_243590

EPH-ephrin mediated repulsion of cells pathway

REACT_220092

GPVI-mediated activation cascade pathway

REACT_258158

EPH-Ephrin signaling pathway

REACT_204733

G alpha (12/13) signalling events pathway

REACT_261840

VEGFR2 mediated vascular permeability pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_261444

Axon guidance pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_188202

FCERI mediated Ca+2 mobilization pathway

REACT_210090

Rho GTPase cycle pathway

REACT_209368

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_248921

Signalling by NGF pathway

REACT_188576

Developmental Biology pathway

REACT_188257

Signal Transduction pathway

REACT_210847

p75 NTR receptor-mediated signalling pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_188188

DAP12 interactions pathway

REACT_188185

DAP12 signaling pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04664

Fc epsilon RI signaling pathway pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04662

B cell receptor signaling pathway pathway

hsa04510

Focal adhesion pathway

hsa04660

T cell receptor signaling pathway pathway

hsa04650

Natural killer cell mediated cytotoxicity pathway

hsa04666

Fc gamma R-mediated phagocytosis pathway

hsa04062

Chemokine signaling pathway pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04650

Natural killer cell mediated cytotoxicity pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04670

Leukocyte transendothelial migration pathway

mmu04510

Focal adhesion pathway

mmu04662

B cell receptor signaling pathway pathway

mmu04666

Fc gamma R-mediated phagocytosis pathway

mmu04062

Chemokine signaling pathway pathway

INOH

PID NCI

rac1_reg_pathway

Regulation of RAC1 activity

ar_pathway

Coregulation of Androgen receptor activity

avb3_integrin_pathway

Integrins in angiogenesis

rhoa_reg_pathway

Regulation of RhoA activity

cdc42_reg_pathway

Regulation of CDC42 activity

avb3_opn_pathway

Osteopontin-mediated events

Cross-References

SwissProt

TrEMBL

E1BBD2 Q45KY0

UniProt Splice Variant

Entrez Gene

521961

UniGene

Bt.109707 Bt.110722 Bt.111065

RefSeq

XM_002686162 XM_005204239 XM_615898

HUGO

HGNC:12659

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007603 DAAA02007604 DAAA02007605 DAAA02007606 DAAA02007607 DAAA02007608 DAAA02007609 DAAA02007610 DAAA02007611 DQ125496

GenPept

AAZ38952

RNA Seq Atlas

521961