Version 5.4
Mus musculus Gene: Vav3
Summary
InnateDB Gene IDBG-188386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vav3
Gene Name vav 3 oncogene
Synonyms A530094I06Rik; AA986410; Idd18.1
Species Mus musculus
Ensembl Gene ENSMUSG00000033721
Encoded Proteins
IDBP-188388
vav 3 oncogene
IDBP-268474
vav 3 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134215:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:109340653-109685698
Strand Forward strand
Band F3
Transcripts
ENSMUST00000046864 ENSMUSP00000036270
ENSMUST00000106576 ENSMUSP00000102186
ENSMUST00000126179
ENSMUST00000137871
ENSMUST00000128033
ENSMUST00000148866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006906 vesicle fusion
GO:0006974 cellular response to DNA damage stimulus
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0016477 cell migration
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030593 neutrophil chemotaxis
GO:0030890 positive regulation of B cell proliferation
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134215
View Gene Order
ENSBTAG00000031575
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_227951
Signaling by VEGF pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_210090
Rho GTPase cycle pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04660
T cell receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_21
RANKL pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
ar_pathway
Coregulation of Androgen receptor activity
avb3_integrin_pathway
Integrins in angiogenesis
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt Q9R0C8
TrEMBL
UniProt Splice Variant
Entrez Gene 57257
UniGene Mm.282257 Mm.403419
RefSeq NM_020505 NM_146139
OMIM
CCDS CCDS17773 CCDS59650
HPRD
IMGT
MGI ID MGI:1888518
MGI Symbol Vav3
EMBL AF067816 AF140280 AK033253 AK041249 AK147053 AL671857 AL671987 AL731716 BC027242 BC052739 CR936838 CR936848 CR936849 CR938729
GenPept AAF09171 AAF20330 AAH27242 AAH52739 BAC28212 BAC30879 BAE27637 CAM14541 CAM16459 CAM18527 CAM28077 CAM28109 CAM28111 CAM28160 CAM28169 CAM28172
RNA Seq Atlas 57257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca