InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AKR1D1

Summary

InnateDB Gene

IDBG-635861.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1D1

Gene Name

3-oxo-5-beta-steroid 4-dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001658

Encoded Proteins

IDBP-687741

aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122787:
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:102576438-102627066

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002172

ENSBTAP00000002172

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0007586	digestion
GO:0008207	C21-steroid hormone metabolic process
GO:0008209	androgen metabolic process
GO:0055114	oxidation-reduction process