InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANXA4

Summary

InnateDB Gene

IDBG-635876.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA4

Gene Name

Annexin A4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001105

Encoded Proteins

IDBP-687756

Annexin A4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20237821

[Homo sapiens] ANXA4 differentially modulates the NF-kappaB signalling pathway and this is dependent on its interactions with NFKB1 and the intracellular Ca(2+) ion level.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196975:
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59%% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68070487-68144492

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001463

ENSBTAP00000001463

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008201	heparin binding
GO:0030246	carbohydrate binding
GO:0035374	chondroitin sulfate binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0030855	epithelial cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:2000483	negative regulation of interleukin-8 secretion

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0012506	vesicle membrane
GO:0016324	apical plasma membrane
GO:0031965	nuclear membrane
GO:0042584	chromaffin granule membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000196975

View Gene Order

ENSMUSG00000029994

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P13214

TrEMBL

Q9TRL6

UniProt Splice Variant

Entrez Gene

281625

UniGene

Bt.38197

RefSeq

NM_001001440

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103381 D78178 M22248 X13627

GenPept

AAA30507 AAI03382 BAA11243 CAA31954

RNA Seq Atlas

281625