Version 5.4
Bos taurus Gene: BT.46623
Summary
InnateDB Gene IDBG-635903.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.46623
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015361
Encoded Proteins
IDBP-687814
ciliary neurotrophic factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122756:
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:77260361-77298847
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061638 ENSBTAP00000053267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019955 cytokine binding
Biological Process
GO:0001967 suckling behavior
GO:0003360 brainstem development
GO:0007548 sex differentiation
GO:0008284 positive regulation of cell proliferation
GO:0043524 negative regulation of neuron apoptotic process
GO:0060538 skeletal muscle organ development
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0016020 membrane
GO:0097059 CNTFR-CLCF1 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000122756
View Gene Order
ENSMUSG00000028444
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MLR4
UniProt Splice Variant
Entrez Gene 539548
UniGene Bt.46623
RefSeq NM_001278571
HUGO HGNC:2170
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023877 DAAA02023878 DAAA02023879
GenPept
RNA Seq Atlas 539548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca