InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CNTFR

Summary

InnateDB Gene

IDBG-59992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNTFR

Gene Name

ciliary neurotrophic factor receptor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000122756

Encoded Proteins

IDBP-59994

ciliary neurotrophic factor receptor

IDBP-59996

ciliary neurotrophic factor receptor

IDBP-367582

ciliary neurotrophic factor receptor

IDBP-810574

ciliary neurotrophic factor receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:34551432-34590140

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000378980	ENSP00000368265
ENST00000351266	ENSP00000242338
ENST00000417345	ENSP00000388082
ENST00000610543	ENSP00000480451

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019955	cytokine binding

Biological Process

GO:0001967	suckling behavior
GO:0003360	brainstem development
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007548	sex differentiation
GO:0008284	positive regulation of cell proliferation
GO:0043524	negative regulation of neuron apoptotic process
GO:0060538	skeletal muscle organ development
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0097059	CNTFR-CLCF1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028444

View Gene Order

ENSBTAG00000015361

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001207011 NM_001842 NM_147164 XM_005251362 XM_005251363 XM_006716720

HUGO

OMIM

CCDS

CCDS6558

HPRD

00348

IMGT

EMBL

GenPept

RNA Seq Atlas