InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NUP153

Summary

InnateDB Gene

IDBG-635914.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP153

Gene Name

nuclear pore complex protein Nup153

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017128

Encoded Proteins

IDBP-687853

nucleoporin 153kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15210729

[Homo sapiens] NUP153 and NUP214 are nucleoporins that control the nucleo-cytoplasmic shuttling and, along with XPO1-dependent nuclear export, the subcellular distribution of latent STAT1.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124789:
Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. The protein encoded by this gene has three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. [provided by RefSeq, Jul 2008]
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:39534812-39605632

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022768

ENSBTAP00000022768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017056	structural constituent of nuclear pore
GO:0042802	identical protein binding
GO:0043495	protein anchor

Biological Process

GO:0046832	negative regulation of RNA export from nucleus
GO:0051292	nuclear pore complex assembly

Cellular Component

GO:0005643	nuclear pore
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket