InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUP153

Summary

InnateDB Gene

IDBG-63405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP153

Gene Name

nucleoporin 153kDa

Synonyms

HNUP153; N153

Species

Homo sapiens

Ensembl Gene

ENSG00000124789

Encoded Proteins

IDBP-63409

nucleoporin 153kDa

IDBP-593086

nucleoporin 153kDa

IDBP-806818

nucleoporin 153kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15210729

NUP153 and NUP214 are nucleoporins that control the nucleo-cytoplasmic shuttling and, along with XPO1-dependent nuclear export, the subcellular distribution of latent STAT1.

Entrez Gene

Summary

Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. The protein encoded by this gene has three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. [provided by RefSeq, Jul 2008]
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:17615035-17706834

Strand

Reverse strand

Band

p22.3

Transcripts

ENST00000262077	ENSP00000262077
ENST00000537253	ENSP00000444029
ENST00000613258	ENSP00000478627

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	57 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005215	transporter activity
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017056	structural constituent of nuclear pore
GO:0042802	identical protein binding
GO:0043495	protein anchor

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046718	viral entry into host cell
GO:0046832	negative regulation of RNA export from nucleus
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly
GO:0055085	transmembrane transport
GO:0075732	viral penetration into host nucleus

Cellular Component

GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket