Version 5.4
Bos taurus Gene: NLGN1
Summary
InnateDB Gene IDBG-636117.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLGN1
Gene Name neuroligin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031891
Encoded Proteins
IDBP-688015
neuroligin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169760:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93626219-93632229
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045228 ENSBTAP00000042636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0016080 synaptic vesicle targeting
GO:0035418 protein localization to synapse
GO:0045184 establishment of protein localization
GO:0045664 regulation of neuron differentiation
GO:0048789 cytoskeletal matrix organization at active zone
GO:0050804 regulation of synaptic transmission
GO:0051260 protein homooligomerization
GO:0072553 terminal button organization
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097115 neurexin clustering
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:2000302 positive regulation of synaptic vesicle exocytosis
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169760
View Gene Order
ENSMUSG00000063887
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.111907
RefSeq NM_001205973
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca