Version 5.4
Homo sapiens Gene: NLGN1
Summary
InnateDB Gene IDBG-65853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLGN1
Gene Name neuroligin 1
Synonyms NL1
Species Homo sapiens
Ensembl Gene ENSG00000169760
Encoded Proteins
IDBP-65857
neuroligin 1
IDBP-293875
neuroligin 1
IDBP-385503
neuroligin 1
IDBP-385504
neuroligin 1
IDBP-385508
neuroligin 1
IDBP-385509
neuroligin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:173396284-174286644
Strand Forward strand
Band q26.31
Transcripts
ENST00000361589 ENSP00000354541
ENST00000401917 ENSP00000385750
ENST00000423427 ENSP00000407255
ENST00000413821 ENSP00000401843
ENST00000457714 ENSP00000392500
ENST00000415045 ENSP00000410374
ENST00000482120
ENST00000466350
ENST00000469564
ENST00000469727
ENST00000490929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0030165 PDZ domain binding
GO:0042043 neurexin family protein binding
GO:0046983 protein dimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006605 protein targeting
GO:0007157 heterophilic cell-cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0008152 metabolic process
GO:0016080 synaptic vesicle targeting
GO:0016339 calcium-dependent cell-cell adhesion
GO:0023041 neuronal signal transduction
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035418 protein localization to synapse
GO:0045184 establishment of protein localization
GO:0045664 regulation of neuron differentiation
GO:0048789 cytoskeletal matrix organization at active zone
GO:0050804 regulation of synaptic transmission
GO:0050808 synapse organization
GO:0051260 protein homooligomerization
GO:0051290 protein heterotetramerization
GO:0051491 positive regulation of filopodium assembly
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060999 positive regulation of dendritic spine development
GO:0072553 terminal button organization
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:0097115 neurexin clustering
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:1900029 positive regulation of ruffle assembly
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1902533 positive regulation of intracellular signal transduction
GO:2000302 positive regulation of synaptic vesicle exocytosis
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032433 filopodium tip
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063887
View Gene Order
ENSBTAG00000031891
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q8N2Q7
TrEMBL
UniProt Splice Variant
Entrez Gene 22871
UniGene Hs.478289 Hs.609781 Hs.690859 Hs.732502
RefSeq NM_014932 XM_005247234 XM_005247235 XM_005247237
HUGO HGNC:14291
OMIM 600568
CCDS CCDS3222
HPRD 07195
IMGT
EMBL AB028993 AC008082 AC008120 AC092923 AC092967 AC110871 AC131158 AK074522 BC032555
GenPept AAH32555 BAA83022 BAC11039
RNA Seq Atlas 22871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca