Version 5.4
| Bos taurus Gene: IL2RG | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-636150.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | IL2RG | ||||||
| Gene Name | Cytokine receptor common subunit gamma | ||||||
| Synonyms | |||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000007626 | ||||||
| Encoded Proteins |
Cytokine receptor common subunit gamma
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| InnateDB Annotation from Orthologs | |||||||
| Summary |
[Homo sapiens] IL2RG physically associates with JAK2, suggesting that regulation of JAK2 may be linked to IL2 induced signal transduction.
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| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147168:
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome X:84816193-84819838 | ||||||
| Strand | Forward strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Interleukin-7 signaling pathway
Hemostasis pathway
Immune System pathway
Interleukin receptor SHC signaling pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
GPCR downstream signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH |
IL2 pathway
IL4 pathway
IL-7 pathway
IL9 pathway
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| REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Interleukin-7 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
Endocytosis pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
Endocytosis pathway
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| INOH |
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
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| PID NCI |
IL2-mediated signaling events
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
IL4-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
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| Cross-References | |||||||
| SwissProt | Q95118 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 281862 | ||||||
| UniGene | Bt.11080 | ||||||
| RefSeq | NM_174359 XM_005227998 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | BC134467 U33748 | ||||||
| GenPept | AAB07812 AAI34468 | ||||||
| RNA Seq Atlas | 281862 | ||||||