Mus musculus Gene: Il2rg | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-163447.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Il2rg | ||||||||||||||||||||||
Gene Name | interleukin 2 receptor, gamma chain | ||||||||||||||||||||||
Synonyms | [g]c; CD132; gamma(c); gc | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031304 | ||||||||||||||||||||||
Encoded Proteins |
interleukin 2 receptor, gamma chain
interleukin 2 receptor, gamma chain
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] IL2RG physically associates with JAK2, suggesting that regulation of JAK2 may be linked to IL2 induced signal transduction.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147168:
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome X:101264378-101268255 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | D | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
Endocytosis pathway
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INOH |
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
IL2 pathway
IL4 pathway
IL-7 pathway
IL9 pathway
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REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Interleukin-7 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Interleukin-7 signaling pathway
Hemostasis pathway
Immune System pathway
Interleukin receptor SHC signaling pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
GPCR downstream signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
Endocytosis pathway
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INOH |
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
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PID NCI |
IL2-mediated signaling events
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
IL4-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.2923 Mm.404153 | ||||||||||||||||||||||
RefSeq | NM_013563 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS30312 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||