InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DLG3

Summary

InnateDB Gene

IDBG-636229.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG3

Gene Name

disks large homolog 3

Synonyms

MPP3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011291

Encoded Proteins

IDBP-688145

discs, large homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082458:
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:85245062-85298606

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015000

ENSBTAP00000015000

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019902	phosphatase binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001736	establishment of planar polarity
GO:0010923	negative regulation of phosphatase activity
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex