InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLG3

Summary

InnateDB Gene

IDBG-74540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG3

Gene Name

discs, large homolog 3 (Drosophila)

Synonyms

MRX; MRX90; NEDLG; PPP1R82; SAP102; XLMR

Species

Homo sapiens

Ensembl Gene

ENSG00000082458

Encoded Proteins

IDBP-74542

discs, large homolog 3 (Drosophila)

IDBP-74544

discs, large homolog 3 (Drosophila)

IDBP-74546

discs, large homolog 3 (Drosophila)

IDBP-597043

discs, large homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:70444861-70505490

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000194900	ENSP00000194900
ENST00000374360	ENSP00000363480
ENST00000374355	ENSP00000363475
ENST00000463252
ENST00000489733
ENST00000494493
ENST00000466140
ENST00000461646
ENST00000496931
ENST00000542398	ENSP00000441393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019902	phosphatase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0001736	establishment of planar polarity
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010923	negative regulation of phosphatase activity
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0030426	growth cone
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0045202	synapse