InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LIF

Summary

InnateDB Gene

IDBG-636335.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIF

Gene Name

Leukemia inhibitory factor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007424

Encoded Proteins

IDBP-688250

Leukemia inhibitory factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128342:
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:71413855-71418166

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009761

ENSBTAP00000009761

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001135	RNA polymerase II transcription factor recruiting transcription factor activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007566	embryo implantation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0019827	stem cell maintenance
GO:0030324	lung development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045595	regulation of cell differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045835	negative regulation of meiosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0046888	negative regulation of hormone secretion
GO:0048286	lung alveolus development
GO:0048644	muscle organ morphogenesis
GO:0048666	neuron development
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0048863	stem cell differentiation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0060135	maternal process involved in female pregnancy
GO:0060426	lung vasculature development
GO:0060463	lung lobe morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182	positive regulation of protein localization to nucleus
GO:1901676	positive regulation of histone H3-K27 acetylation