Version 5.4
Homo sapiens Gene: LIF
Summary
InnateDB Gene IDBG-3968.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIF
Gene Name leukemia inhibitory factor
Synonyms CDF; DIA; HILDA; MLPLI
Species Homo sapiens
Ensembl Gene ENSG00000128342
Encoded Proteins
IDBP-3970
leukemia inhibitory factor (cholinergic differentiation factor)
IDBP-294599
leukemia inhibitory factor (cholinergic differentiation factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30240447-30246851
Strand Reverse strand
Band q12.2
Transcripts
ENST00000249075 ENSP00000249075
ENST00000403987 ENSP00000384450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001135 RNA polymerase II transcription factor recruiting transcription factor activity
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005146 leukemia inhibitory factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001974 blood vessel remodeling
GO:0006366 transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007275 multicellular organismal development
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0019827 stem cell maintenance
GO:0030324 lung development
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410 positive regulation of MAPK cascade
GO:0045595 regulation of cell differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045835 negative regulation of meiosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0046888 negative regulation of hormone secretion
GO:0048286 lung alveolus development
GO:0048644 muscle organ morphogenesis
GO:0048666 neuron development
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0048863 stem cell differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0060135 maternal process involved in female pregnancy
GO:0060426 lung vasculature development
GO:0060463 lung lobe morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182 positive regulation of protein localization to nucleus
GO:1901676 positive regulation of histone H3-K27 acetylation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034394
View Gene Order
ENSBTAG00000007424
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
LIF signaling pathway
INOH website
GPCR signaling pathway
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt P15018
TrEMBL
UniProt Splice Variant
Entrez Gene 3976
UniGene Hs.2250 Hs.605598
RefSeq NM_001257135 NM_002309 XM_005261601 XM_006724240
HUGO HGNC:6596
OMIM 159540
CCDS CCDS13872 CCDS58799
HPRD
IMGT
EMBL AC004264 AK315310 BC069540 BC093733 BC093735 CH471095 CN409468 J03261 M27052 M27053 M63420 X13967
GenPept AAA51699 AAA53188 AAA59517 AAC05174 AAH69540 AAH93733 AAH93735 BAG37714 CAA32147 EAW59863
RNA Seq Atlas 3976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca