InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SERPINC1

Summary

InnateDB Gene

IDBG-636347.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINC1

Gene Name

antithrombin-III precursor

Synonyms

AT3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004362

Encoded Proteins

IDBP-688267

antithrombin-III precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117601:
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:56723665-56734280

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005713

ENSBTAP00000005713

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding