Version 5.4
Bos taurus Gene: PES1
Summary
InnateDB Gene IDBG-636490.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PES1
Gene Name pescadillo homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007728
Encoded Proteins
IDBP-688418
pescadillo homolog 1, containing BRCT domain (zebrafish)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100029:
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:71681088-71700449
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010163 ENSBTAP00000010163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0007000 nucleolus organization
GO:0033365 protein localization to organelle
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100029
View Gene Order
ENSMUSG00000020430
View Gene Order
Cross-References
SwissProt
TrEMBL E1BM72
UniProt Splice Variant
Entrez Gene 511676
UniGene
RefSeq NM_001192300
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045628 DAAA02045629 DAAA02045630 DAAA02045631
GenPept
RNA Seq Atlas 511676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca