Version 5.4
Homo sapiens Gene: PES1
Summary
InnateDB Gene IDBG-4252.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PES1
Gene Name pescadillo ribosomal biogenesis factor 1
Synonyms PES
Species Homo sapiens
Ensembl Gene ENSG00000100029
Encoded Proteins
IDBP-4254
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-4256
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-294499
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-294501
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-294500
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-294497
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-372080
pescadillo homolog 1, containing BRCT domain (zebrafish)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30576625-30607083
Strand Reverse strand
Band q12.2
Transcripts
ENST00000335214 ENSP00000334612
ENST00000354694 ENSP00000346725
ENST00000402284 ENSP00000384252
ENST00000406208 ENSP00000384777
ENST00000402281 ENSP00000384366
ENST00000405677 ENSP00000385654
ENST00000441668 ENSP00000404234
ENST00000433575
ENST00000488719
ENST00000477762
ENST00000466614
ENST00000467368
ENST00000492986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0007000 nucleolus organization
GO:0008283 cell proliferation
GO:0033365 protein localization to organelle
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020430
View Gene Order
ENSBTAG00000007728
Not yet available
Cross-References
SwissProt O00541
TrEMBL B2RDF2 B3KXD6
UniProt Splice Variant
Entrez Gene 23481
UniGene Hs.517543
RefSeq NM_014303 XM_006724173 NM_001243225 NM_001282327 NM_001282328
HUGO HGNC:8848
OMIM 605819
CCDS CCDS13880 CCDS58802 CCDS74842
HPRD 05783
IMGT
EMBL AB451380 AC005006 AK127185 AK315518 BC032489 CH471095 CR456539 U78310
GenPept AAB61140 AAH32489 BAG37899 BAG54448 BAG70194 CAG30425 EAW59904 EAW59905 EAW59906
RNA Seq Atlas 23481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca