Version 5.4
| Bos taurus Gene: FANCC | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-636496.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | FANCC | ||||||||||||
| Gene Name | Fanconi anemia group C protein homolog | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000017195 | ||||||||||||
| Encoded Proteins |
Fanconi anemia group C protein homolog
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] FANCC is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment. (Demonstrated in mice)
[Mus musculus] Fancc is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment.
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158169:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 8:83023629-83270596 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Fanconi Anemia pathway pathway
DNA Repair pathway
DNA Repair pathway
Fanconi Anemia pathway pathway
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| KEGG | |||||||||||||
| INOH | |||||||||||||
| PID NCI |
Fanconi anemia pathway
BARD1 signaling events
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | A5PJJ8 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 281762 | ||||||||||||
| UniGene | Bt.4648 | ||||||||||||
| RefSeq | NM_174316 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC142139 DAAA02023993 DAAA02023994 DAAA02023995 DAAA02023996 DAAA02023997 DAAA02023998 DAAA02023999 | ||||||||||||
| GenPept | AAI42140 | ||||||||||||
| RNA Seq Atlas | 281762 | ||||||||||||