Version 5.4
Mus musculus Gene: Fancc
Summary
InnateDB Gene IDBG-160833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fancc
Gene Name Fanconi anemia, complementation group C
Synonyms Facc
Species Mus musculus
Ensembl Gene ENSMUSG00000021461
Encoded Proteins
IDBP-160837
Fanconi anemia, complementation group C
IDBP-160839
Fanconi anemia, complementation group C
IDBP-539616
Fanconi anemia, complementation group C
IDBP-540967
Fanconi anemia, complementation group C
IDBP-532785
Fanconi anemia, complementation group C
IDBP-540761
Fanconi anemia, complementation group C
IDBP-539786
Fanconi anemia, complementation group C
IDBP-531692
Fanconi anemia, complementation group C
IDBP-541487
Fanconi anemia, complementation group C
IDBP-537173
Fanconi anemia, complementation group C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22106009
Fancc is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment.
InnateDB Annotation from Orthologs
Summary
PMID 22106009
[Homo sapiens] FANCC is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158169:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:63304709-63497278
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000073029 ENSMUSP00000072788
ENSMUST00000099444 ENSMUSP00000097043
ENSMUST00000161977 ENSMUSP00000123817
ENSMUST00000160166
ENSMUST00000163091 ENSMUSP00000124406
ENSMUST00000160336
ENSMUST00000160333
ENSMUST00000159056
ENSMUST00000160151
ENSMUST00000161656
ENSMUST00000160735 ENSMUSP00000125710
ENSMUST00000162971 ENSMUSP00000123972
ENSMUST00000162375 ENSMUSP00000124759
ENSMUST00000161507
ENSMUST00000159024 ENSMUSP00000124325
ENSMUST00000160931 ENSMUSP00000124165
ENSMUST00000160617 ENSMUSP00000123767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002262 myeloid cell homeostasis
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0007276 gamete generation
GO:0007281 germ cell development
GO:0019430 removal of superoxide radicals
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043240 Fanconi anaemia nuclear complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158169
View Gene Order
ENSBTAG00000017195
Not yet available
Pathways
NETPATH
REACTOME
REACT_233397
DNA Repair pathway
REACT_232842
Fanconi Anemia pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18410
Fanconi Anemia pathway pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
bard1pathway
BARD1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.126106 Mm.405335 Mm.465019
RefSeq NM_001042673 NM_001282942 NM_007985 XM_006517087 XM_006517089 XM_006517090 XM_006517091 XM_006517092 XM_006517093
OMIM
CCDS CCDS36700 CCDS70472
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca