InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: F13A1

Summary

InnateDB Gene

IDBG-636530.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F13A1

Gene Name

Coagulation factor XIII A chain

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007268

Encoded Proteins

IDBP-688461

Coagulation factor XIII A chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124491:
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:48633936-48776698

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009559

ENSBTAP00000009559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0046872	metal ion binding