Bos taurus Protein: F13A1 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-688461.2 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | F13A1 | ||||||||||
Protein Name | Coagulation factor XIII A chain | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Protein | ENSBTAP00000009559 | ||||||||||
InnateDB Gene | IDBG-636530 (F13A1) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. | ||||||||||
Subcellular Localization | Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR001102
Transglutaminase, N-terminal IPR002931 Transglutaminase-like IPR008958 Transglutaminase, C-terminal IPR014756 Immunoglobulin E-set |
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PFAM |
PF00868
PF01841 PF00927 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00460
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P12260 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | Q27982 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 617881 | ||||||||||
UniGene | Bt.19195 | ||||||||||
RefSeq | NP_001161366 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | BT025350 DAAA02055840 DAAA02055841 DAAA02055842 DAAA02055843 DAAA02055844 DAAA02055845 U13392 | ||||||||||
GenPept | AAB60265 ABF57306 | ||||||||||