Version 5.4
Bos taurus Gene: BT.37907
Summary
InnateDB Gene IDBG-636575.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.37907
Gene Name RNA binding protein fox-1 homolog 1
Synonyms A2BP1; FOX1
Species Bos taurus
Ensembl Gene ENSBTAG00000007210
Encoded Proteins
IDBP-688511
fox-1 homolog A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078328:
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:6481524-6686788
Strand Forward strand
Band
Transcripts
ENSBTAT00000009490 ENSBTAP00000009490
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0043484 regulation of RNA splicing
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078328
View Gene Order
ENSMUSG00000008658
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115781
Bmal1:Clock,Npas2 activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MWC7
UniProt Splice Variant
Entrez Gene 521304
UniGene Bt.37907
RefSeq NM_001075818
HUGO HGNC:18222
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057383 DAAA02057384 DAAA02057385
GenPept
RNA Seq Atlas 521304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca