Version 5.4
Mus musculus Gene: Rbfox1
Summary
InnateDB Gene IDBG-131279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbfox1
Gene Name RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000008658
Encoded Proteins
IDBP-131281
RNA binding protein, fox-1 homolog (C. elegans) 1
IDBP-248753
RNA binding protein, fox-1 homolog (C. elegans) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078328:
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:6809222-7412479
Strand Forward strand
Band A1
Transcripts
ENSMUST00000056416 ENSMUSP00000049970
ENSMUST00000115841 ENSMUSP00000111507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078328
View Gene Order
ENSBTAG00000007210
Not yet available
Pathways
NETPATH
REACTOME
REACT_115781
Bmal1:Clock,Npas2 activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.395256 Mm.398989
RefSeq NM_021477 NM_183188 XM_006522159 XM_006522182 XM_006522188
OMIM
CCDS CCDS27936 CCDS37245
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca