InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RYR1

Summary

InnateDB Gene

IDBG-636624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYR1

Gene Name

ryanodine receptor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006999

Encoded Proteins

IDBP-689165

ryanodine receptor 1 (skeletal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196218:
This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:48502352-48631056

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009228

ENSBTAP00000009228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0001666	response to hypoxia
GO:0003151	outflow tract morphogenesis
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006936	muscle contraction
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0043588	skin development
GO:0043931	ossification involved in bone maturation
GO:0048741	skeletal muscle fiber development
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071313	cellular response to caffeine

Cellular Component

GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030314	junctional membrane complex
GO:0030315	T-tubule
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome