InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RYR1

Summary

InnateDB Protein

IDBP-689165.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYR1

Protein Name

ryanodine receptor 1 (skeletal)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009228

InnateDB Gene

IDBG-636624 (RYR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0001666	response to hypoxia
GO:0003151	outflow tract morphogenesis
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006936	muscle contraction
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0043588	skin development
GO:0043931	ossification involved in bone maturation
GO:0048741	skeletal muscle fiber development
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071313	cellular response to caffeine

Cellular Component

GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030314	junctional membrane complex
GO:0030315	T-tubule
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPRY domain
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM