Version 5.4
Bos taurus Gene: ARAF
Summary
InnateDB Gene IDBG-636714.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAF
Gene Name serine/threonine-protein kinase A-Raf
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005039
Encoded Proteins
IDBP-688669
serine/threonine-protein kinase A-Raf
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078061:
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:91180863-91191308
Strand Forward strand
Band
Transcripts
ENSBTAT00000006646 ENSBTAP00000006646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078061
View Gene Order
ENSMUSG00000001127
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04720
Long-term potentiation pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04730
Long-term depression pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05160
Hepatitis C pathway
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu05210
Colorectal cancer pathway
mmu05218
Melanoma pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu05215
Prostate cancer pathway
mmu04730
Long-term depression pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
FGF8 signaling (Mouse) pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q2KJA0 Q5BIM4
UniProt Splice Variant
Entrez Gene 540421
UniGene Bt.39553
RefSeq NM_001014964
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105445 BT021200 DAAA02073028
GenPept AAI05446 AAX31382
RNA Seq Atlas 540421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca