Version 5.4
Homo sapiens Gene: ARAF
Summary
InnateDB Gene IDBG-61504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAF
Gene Name v-raf murine sarcoma 3611 viral oncogene homolog
Synonyms A-RAF; ARAF1; PKS2; RAFA1
Species Homo sapiens
Ensembl Gene ENSG00000078061
Encoded Proteins
IDBP-61506
v-raf murine sarcoma 3611 viral oncogene homolog
IDBP-61508
v-raf murine sarcoma 3611 viral oncogene homolog
IDBP-61510
v-raf murine sarcoma 3611 viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47561100-47571920
Strand Forward strand
Band p11.3
Transcripts
ENST00000377045 ENSP00000366244
ENST00000290277 ENSP00000290277
ENST00000377039 ENSP00000366238
ENST00000489496
ENST00000469505
ENST00000470206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0032006 regulation of TOR signaling
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001127
View Gene Order
ENSBTAG00000005039
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04720
Long-term potentiation pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04730
Long-term depression pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P10398
TrEMBL A0A024R178 Q59HC8 Q96II5
UniProt Splice Variant
Entrez Gene 369
UniGene Hs.446641
RefSeq NM_001256196 NM_001256197 NM_001654 XM_006724529
HUGO HGNC:646
OMIM 311010
CCDS CCDS35232 CCDS59164 CCDS75970
HPRD
IMGT
EMBL AB158254 AB208831 AL542736 BC002466 BC007514 BT019864 CH471164 L24038 M13829 U01337 X04790 Z84466
GenPept AAA65219 AAB03517 AAB08754 AAH02466 AAH07514 AAV38667 BAD92068 BAE66645 CAA28476 CAI42468 CAI42469 EAW59311 EAW59312
RNA Seq Atlas 369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca