InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CFP

Summary

InnateDB Gene

IDBG-636742.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFP

Gene Name

properdin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015815

Encoded Proteins

IDBP-688700

properdin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18579773

[Homo sapiens] CFP binds to early apoptotic T cells and initiates complement activation, leading to C3B opsonization and ingestion by phagocytic cells.

PMID 25725105

[Mus musculus] Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126759:
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:91441704-91447087

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021009

ENSBTAP00000021009

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.