InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALKBH3

Summary

InnateDB Gene

IDBG-636865.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH3

Gene Name

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009518

Encoded Proteins

IDBP-688841

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166199:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:74847959-74889003

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012522

ENSBTAP00000012522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734	DNA-N1-methyladenine dioxygenase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0008283	cell proliferation
GO:0035552	oxidative single-stranded DNA demethylation
GO:0055114	oxidation-reduction process