Version 5.4
Homo sapiens Gene: ALKBH3
Summary
InnateDB Gene IDBG-40555.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH3
Gene Name alkB, alkylation repair homolog 3 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166199
Encoded Proteins
IDBP-40557
alkB, alkylation repair homolog 3 (E. coli)
IDBP-589900
alkB, alkylation repair homolog 3 (E. coli)
IDBP-598344
alkB, alkylation repair homolog 3 (E. coli)
IDBP-587470
alkB, alkylation repair homolog 3 (E. coli)
IDBP-597400
alkB, alkylation repair homolog 3 (E. coli)
IDBP-590083
alkB, alkylation repair homolog 3 (E. coli)
IDBP-599393
alkB, alkylation repair homolog 3 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:43880811-43920266
Strand Forward strand
Band p11.2
Transcripts
ENST00000302708 ENSP00000302232
ENST00000532962 ENSP00000434832
ENST00000527029
ENST00000534171 ENSP00000432259
ENST00000524742 ENSP00000434229
ENST00000530803 ENSP00000436788
ENST00000529366 ENSP00000435848
ENST00000533200
ENST00000530754
ENST00000532410
ENST00000532129 ENSP00000433614
ENST00000529434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
GO:0043734 DNA-N1-methyladenine dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0008283 cell proliferation
GO:0035552 oxidative single-stranded DNA demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040174
View Gene Order
ENSBTAG00000009518
Not yet available
Pathways
NETPATH
REACTOME
REACT_1662
ABH3 mediated Reversal of Alkylation Damage pathway
REACT_127
DNA Damage Reversal pathway
REACT_2020
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.714100 Hs.720708
RefSeq NM_139178
HUGO
OMIM
CCDS CCDS7906
HPRD 16793
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca