InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ROR2

Summary

InnateDB Gene

IDBG-637006.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROR2

Gene Name

tyrosine-protein kinase transmembrane receptor ROR2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005092

Encoded Proteins

IDBP-688984

receptor tyrosine kinase-like orphan receptor 2

IDBP-688985

receptor tyrosine kinase-like orphan receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169071:
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:87340388-87578642

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061589	ENSBTAP00000053765
ENSBTAT00000052693	ENSBTAP00000047539

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001756	somitogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007254	JNK cascade
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030538	embryonic genitalia morphogenesis
GO:0042472	inner ear morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway