Version 5.4
Homo sapiens Gene: ROR2
Summary
InnateDB Gene IDBG-75748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROR2
Gene Name receptor tyrosine kinase-like orphan receptor 2
Synonyms BDB; BDB1; NTRKR2
Species Homo sapiens
Ensembl Gene ENSG00000169071
Encoded Proteins
IDBP-75750
receptor tyrosine kinase-like orphan receptor 2
IDBP-75754
receptor tyrosine kinase-like orphan receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:91563091-91950162
Strand Reverse strand
Band q22.31
Transcripts
ENST00000375715 ENSP00000364867
ENST00000375708 ENSP00000364860
ENST00000495386
ENST00000476440
ENST00000493846
ENST00000550066
ENST00000548585
ENST00000546883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017147 Wnt-protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001756 somitogenesis
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030538 embryonic genitalia morphogenesis
GO:0042472 inner ear morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021464
View Gene Order
ENSBTAG00000005092
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_172581
PCP/CE pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_172631
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
KEGG
INOH
PID NCI
wnt_signaling_pathway
Wnt signaling network
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.735041 Hs.98255
RefSeq NM_004560 XM_005252008 XM_005252009 XM_006717121
HUGO
OMIM
CCDS CCDS6691
HPRD 03822
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca