InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ERCC4

Summary

InnateDB Gene

IDBG-637090.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC4

Gene Name

DNA repair endonuclease XPF

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021773

Encoded Proteins

IDBP-689086

excision repair cross-complementing rodent repair deficiency, complementation group 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175595:
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5\' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:12923482-12961007

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046336

ENSBTAP00000043645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001094	TFIID-class transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043566	structure-specific DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411	response to UV
GO:0009650	UV protection
GO:0010834	telomere maintenance via telomere shortening
GO:0032205	negative regulation of telomere maintenance
GO:0033683	nucleotide-excision repair, DNA incision
GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0000110	nucleotide-excision repair factor 1 complex
GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex